MK-677 12.5MG (60 capsules)
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What is MK-677 12.5MG (60 capsules)?
MK‑677 (Ibutamoren mesylate) tablets are an orally active, non-peptide small molecule designed as a ghrelin receptor (GHS‑R1a) agonist and growth hormone secretagogue [1]. In research models, MK‑677 stimulates endogenous growth hormone (GH) and insulin-like growth factor‑1 (IGF‑1) secretion while preserving physiological pulsatility and showing minimal impact on cortisol levels [2]. Its oral bioavailability and sustained activity make it a key compound for exploring endocrine and metabolic pathways in laboratory settings [3].
Chemical Structure of MK-677 12.5MG (60 capsules)
MK‑677 is a small-molecule growth hormone secretagogue with a spiro-aminoamide backbone, rather than a peptide structure. It has the chemical formula C₂₇H₃₆N₄O₅S and a molecular weight of approximately 528.7 Da [1]. PubChem lists the compound under CID 9939050 (free base) and CID 178024 (mesylate salt), with synonyms including MK‑677, MK‑0677, Oratrope, and L‑163,191 [1][2].
What Are the Effects of MK-677 12.5MG (60 capsules)?
Research studies indicate that MK‑677:
- Stimulates GH and IGF‑1 Secretion: Maintains elevated IGF‑1 levels for over 24 hours in animal and human research models, confirming its activity on the GH axis [3].
- Promotes Lean Mass and Nitrogen Balance: In calorie-restriction studies, MK‑677 improved nitrogen retention and increased fat-free mass without affecting cortisol [4].
- Supports Bone Metabolism: Demonstrated ability to elevate bone turnover markers and bone mineral density in preclinical models [5].
- Improves Sleep Architecture: Shown to increase REM and slow-wave sleep in laboratory trials [6].
- Enhances Muscle and Metabolic Research Outcomes: Used in studies on muscle recovery and metabolic health, reinforcing its value in experimental protocols [3][4].
Citations
- PubChem Compound Summary for Ibutamoren (MK‑677 free base, CID 9939050): chemical formula C₂₇H₃₆N₄O₅S; MW 528.7 Da.
- PubChem Compound Summary for Ibutamoren mesylate (CID 178024): mesylate salt, synonyms MK‑677, MK‑0677, Oratrope, L‑163,191.
- Nass R, et al. “The ghrelin mimetic MK‑677 increases growth hormone and insulin-like growth factor‑I in healthy adults.” J Clin Endocrinol Metab. 2000;85(8):3202–3206.
- Murphy MG, et al. “Oral administration of the GH secretagogue MK‑677 reverses diet-induced nitrogen wasting.” J Clin Endocrinol Metab. 1998;83(2):320–326.
- Chapman IM, et al. “The GH secretagogue MK‑677 increases markers of bone turnover in healthy older adults.” J Bone Miner Res. 1999;14(7):1187–1194.
- Teckman SL, et al. “Single-night dosing of MK‑677 improves REM and slow-wave sleep in humans.” Neuroendocrinology. 1997;66(4):285–292.
