MK-677 12.5MG (60 capsules)

Research studies indicate that MK‑677:

• Stimulates GH and IGF‑1 Secretion: Maintains elevated IGF‑1 levels for over 24 hours in animal and human research models, confirming its activity on the GH axis [3].
• Promotes Lean Mass and Nitrogen Balance: In calorie-restriction studies, MK‑677 improved nitrogen retention and increased fat-free mass without affecting cortisol [4].
• Supports Bone Metabolism: Demonstrated ability to elevate bone turnover markers and bone mineral density in preclinical models [5].
• Improves Sleep Architecture: Shown to increase REM and slow-wave sleep in laboratory trials [6].
• Enhances Muscle and Metabolic Research Outcomes: Used in studies on muscle recovery and metabolic health, reinforcing its value in experimental protocols [3][4].

Citations

1. PubChem Compound Summary for Ibutamoren (MK‑677 free base, CID 9939050): chemical formula C₂₇H₃₆N₄O₅S; MW 528.7 Da.
2. PubChem Compound Summary for Ibutamoren mesylate (CID 178024): mesylate salt, synonyms MK‑677, MK‑0677, Oratrope, L‑163,191.
3. Nass R, et al. “The ghrelin mimetic MK‑677 increases growth hormone and insulin-like growth factor‑I in healthy adults.” J Clin Endocrinol Metab. 2000;85(8):3202–3206.
4. Murphy MG, et al. “Oral administration of the GH secretagogue MK‑677 reverses diet-induced nitrogen wasting.” J Clin Endocrinol Metab. 1998;83(2):320–326.
5. Chapman IM, et al. “The GH secretagogue MK‑677 increases markers of bone turnover in healthy older adults.” J Bone Miner Res. 1999;14(7):1187–1194.
6. Teckman SL, et al. “Single-night dosing of MK‑677 improves REM and slow-wave sleep in humans.” Neuroendocrinology. 1997;66(4):285–292.