GonadorelinAvailability: 43 in stock
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Availability: 43 in stock
The amino acid sequence of Gonadorelin is pGlu–His–Trp–Ser–Tyr–Gly–Leu–Arg–Pro–Gly–NH₂, with a molecular formula of C₅₅H₇₅N₁₇O₁₃ and a molecular weight of approximately 1,182.3 Da.
It features a pyroglutamate (pGlu) at the N-terminus and an amidated C-terminus, which provide enhanced structural stability. Due to its short biological half-life (approximately 10–40 minutes in experimental models), Gonadorelin is often administered in pulsatile patterns to replicate natural GnRH secretion dynamics.
In laboratory studies, Gonadorelin has been shown to:
Stimulate LH and FSH release by activating GnRH receptors in the pituitary.
Model pulsatile GnRH secretion, enabling controlled studies of reproductive hormone cycles.
Support research on ovulation, testosterone regulation, and fertility mechanisms.
Facilitate studies on endocrine feedback loops involving sex steroids, inhibin, and hypothalamic signaling.
Assist in cancer research, particularly in hormone-sensitive prostate and breast cell line studies where GnRH analogues are being evaluated for potential antiproliferative effects.
Gonadorelin is supplied for laboratory research use only and is not approved for human or veterinary consumption.
Gonadorelin
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GonadorelinAvailability: 43 in stock