T-GLP-1
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What is T-GLP-1?
Chemical Structure of T-GLP-1
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Peptide Length: 39 amino acids, based on the human GIP sequence, with modifications from GLP-1 and unique residues.
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Non-standard Modifications:
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Two α-aminoisobutyric acid (Aib) residues at positions 2 and 13, enhancing stability and prolonging half-life.
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A C-terminal amidation and position-20 lysine side chain acylated with a C20 fatty diacid moiety via γ-Glu and bis-(aminoethoxy) linkers, increasing albumin binding and enabling once-weekly dosing
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Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈
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Molecular Weight: Approximately 4,813.45 Da
What Are the Effects of T-GLP-1?
Pharmacology & Mechanism:
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Acts as a dual agonist at GLP-1 and GIP receptors, with higher relative potency at the GIP receptor but effective GLP-1 activity, offering greater metabolic benefits and tolerability.
Therapeutic Effects (as demonstrated in clinical trials):
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Type 2 Diabetes Management: Produces substantial reductions in HbA1c levels, significantly outperforming traditional GLP-1 receptor agonists.
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Weight Loss: Induces considerable weight reduction—in some trials achieving up to ~20% body weight loss over several months.
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Improved Glycemic Control & Insulin Sensitivity: Enhances insulin secretion, lowers fasting and postprandial blood glucose, and supports β-cell function.
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Extended Duration of Action: Owing to its fatty-acid modification and albumin binding, it has a long half-life (~5 days), enabling once-weekly dosing.
Research & Clinical Implications:
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Seen as a “twincretin” molecule, its dual incretin receptor activation provides superior metabolic outcomes vs. selective agents.
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It represents a new paradigm in treating metabolic diseases by targeting multiple hormonal pathways simultaneously.
T-GLP-1
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