What is BPC-157 (10MG)?
Chemical Structure of BPC-157 (10MG)
This pentadecapeptide has the sequence: Gly–Glu–Pro–Pro–Pro–Gly–Lys–Pro–Ala–Asp–Asp–Ala–Gly–Leu–Val, with a molecular formula of C₆₂H₉₈N₁₆O₂₂ and molecular weight approximately 1,419.5 Da [3][4]. It is stable under room temperature and demonstrates resilience in gastric conditions, making it viable for various routes of administration in experimental models [4][7].
What Are the Effects of BPC-157 (10MG)?
Tissue Regeneration & Wound Healing:
Preclinical studies in rodents report accelerated healing of tendons, ligaments, skin wounds, and muscle injuries, correlating with increased fibroblast growth, collagen synthesis, and angiogenesis [5][6][8].
Gastrointestinal Protection:
Demonstrated anti‑ulcer and cytoprotective effects in gastric injury models, with regulated villus‑crypt structure and intestinal tissue preservation [7].
Angiogenesis & Vascular Repair:
Stimulates vascular endothelial growth factor (VEGF) signaling and nitric oxide pathways, promoting blood vessel formation in ischemic and injury models [4][7][9].
Neuro‑ & Organ‑Protection:
Experimental findings suggest BPC‑157 mitigates brain and nerve injury, maintains liver and kidney integrity under toxic stress, and reduces inflammatory markers [5][11].
Anti‑Inflammatory & Oxidative Stress Reduction:
Modulates nitric oxide and inflammatory cytokines, displaying both antioxidant and analgesic effects in animal research [4][7][11].
Safety Profile:
To date, studies report low toxicity and no significant adverse immunogenic or endocrine reactions under laboratory conditions [5][10].
Citations
- PubChem, “BPC‑157 Compound Summary,” NCBI PubChem, CID 9941957.
- BPC‑157 Peptide, Peptide Sciences, “What is BPC‑157 Peptide?”
- PubChem, BPC‑157 molecular data (formula, weight).
- PubChem, physicochemical properties and stability data.
- S. Seiwerth et al., “Stable Gastric Pentadecapeptide BPC‑157 and Wound Healing,” Front. Pharmacol., 2021, 12:627533.
- M. Staresinic et al., “Gastric pentadecapeptide BPC‑157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocyte growth,” J Orthop Res., 2003, 21(6):976–983.
- Chung‑Hsun Chang, W.‑C. Tsai, M.‑S. Lin et al., “The promoting effect of pentadecapeptide BPC‑157 on tendon healing involves tendon outgrowth, cell survival, and cell migration,” J Appl Physiol., 2011, 110(3):774–780.
- “Stable gastric pentadecapeptide BPC‑157: novel therapy in gastrointestinal tract,” Curr Pharm Des., 2011.
- BPC‑157 peptide promotes angiogenesis via VEGFR2 and nitric oxide signaling in ischemic models.
- Peptides.org, “BPC‑157 Reviews, Clinical Trials, and Safety,”
- T. Cerovecki et al., “Pentadecapeptide BPC‑157 (PL 14736) improves ligament healing in the rat,” J Orthop Res., 2010, 28(9):1155–1161.
