5-Amino-1MQ
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What is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small-molecule research compound studied for its ability to inhibit the enzyme nicotinamide N-methyltransferase (NNMT). NNMT plays an important role in regulating cellular metabolism and NAD+ (nicotinamide adenine dinucleotide) availability.
By blocking NNMT activity, 5-Amino-1MQ allows researchers to investigate:
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NAD+ metabolism
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Cellular energy regulation
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Metabolic signaling pathways
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Stress-response mechanisms
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Cell resilience and molecular adaptation
Because of these properties, 5-Amino-1MQ is widely used in laboratory research involving cellular bioenergetics and metabolic regulation.
This compound is intended exclusively for scientific study and is not for human or animal use.
Chemical Structure of 5-Amino-1MQ
5-Amino-1MQ is a synthetic quinolinium-based small molecule. It features:
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A quinolinium core structure
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A methyl group at the 1-position
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An amino group at the 5-position
This structure enables the compound to interact with NNMT by competitively inhibiting the enzyme’s catalytic function.
Key structural characteristics include:
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High stability in solid form
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Efficient solubility for laboratory preparation
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A cationic aromatic system that supports enzyme-binding studies
The molecule’s well-defined chemical stability makes it suitable for controlled metabolic and cellular research applications.
What Are the Effects of 5-Amino-1MQ?
Research findings (in vitro and preclinical models) describe the following scientific effects:
• NNMT Enzyme Inhibition
5-Amino-1MQ is primarily used to study:
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How NNMT inhibition affects NAD+ levels
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The downstream impact of altered methylation pathways
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Cellular energy usage and ATP-related processes
• NAD+ Pathway Research
By modulating NNMT activity, researchers use 5-Amino-1MQ to observe:
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Changes in NAD+ availability
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Shifts in mitochondrial function
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Altered metabolic signaling and cellular adaptation
• Cellular Energy & Metabolism Studies
Laboratory studies use 5-Amino-1MQ to explore:
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Energy balance within cells
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Regulation of metabolic pathways
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Cellular responses under stress or altered signaling
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Molecular resilience and recovery mechanisms
• Consistency in Laboratory Testing
5-Amino-1MQ is valued for:
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High stability in vial form
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Reliable reconstitution for experiments
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Consistent performance in controlled scientific studies
These findings are limited to laboratory-based research and do not reflect any clinical or therapeutic use.
Research-Use Only Disclaimer
This product is intended strictly for scientific and laboratory research.
It is not for human consumption, medical use, diagnostic use, or veterinary use.
No dosing, safety, or clinical guidance is provided.
5-Amino-1MQ
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