5-Amino-1MQ 50MG (60 capsules)

NNMT Inhibition & Enhanced NAD⁺ Availability:

By blocking NNMT activity, 5‑Amino‑1MQ conserves nicotinamide and maintains NAD⁺ levels, supporting mitochondrial bioenergetics and metabolic homeostasis in preclinical models [2][3].

Adipose Tissue Reduction:

In mice with diet-induced obesity, treatment with 5‑Amino‑1MQ decreased body fat percentage, reduced adipocyte size, and improved serum lipid profiles—without altering food intake [2].

Stem/Progenitor Cell Activation:

The increase in NAD⁺ and methyl-donor availability is linked to satellite cell proliferation and improved tissue regenerative capacity in muscle injury studies [3][4].

Anti-Inflammatory and Metabolic Lipid Signatures:

NNMT suppression led to shifts in lipid biomarkers associated with anti-inflammatory and insulin-sensitizing PAHSA lipids, indicating downstream metabolic effects [2][5].

Early Anticancer Potential:

High NNMT expression in tumors has prompted evaluation of 5‑Amino‑1MQ as a metabolic inhibitor in oncology research, with initial in vitro reductions in tumor cell viability [2].

Citations

1. PubChem Compound Summary for 5‑Amino‑1MQ (CID 950107): molecular formula C₁₀H₁₁N₂⁺; exact mass 159.21 Da.
2. Ulanovskaya OA, et al. “NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink.” Nature. 2013;50:246–250. PMID: 23960236.
3. Kraus D, et al. “Nicotinamide-N-methyltransferase knockdown protects against diet-induced obesity.” Nature. 2014;508(7495):258–262. PMID: 24670635.
4. Jarrell DK, et al. “Methionine metabolism in NAD⁺ regulation and tissue regeneration studies.” Cell Metab. 2018;27(2):345–356. PMID: 29449336.
5. Yore MM, et al. “PALMITIC ACID HYDROXY STEARIC ACID (PAHSA) AMELiorates metabolic conditions.” Cell. 2014;158(3):528–539. PMID: 25035482.